Adipose tissue is required for the antidiabetic, but not for the hypolipidemic, effect of thiazolidinediones

There is uncertainty about the site(s) of action of the antidiabetic thiazolidinediones (TZDs). These drugs are agonist ligands of the transcription factor PPARγ, which is abundant in adipose tissue but is normally present at very low levels in liver and muscle. We have studied the effects of TZDs i...

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Vydáno v:	J Clin Invest
Hlavní autoři:	Chao, Lily, Marcus-Samuels, Bernice, Mason, Mark M., Moitra, Jaideep, Vinson, Charles, Arioglu, Elif, Gavrilova, Oksana, Reitman, Marc L.
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	American Society for Clinical Investigation 2000
Témata:	Article
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC381440/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11086023/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI11245
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