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Lack of Adiponectin Drives Hyperosteoclastogenesis in Lipoatrophic Mice

Long bones from mammals host blood cell formation and contain multiple cell types, including adipocytes. Physiological functions of bone marrow adipocytes are poorly documented. Herein, we used adipocyte-deficient PPARγ-whole body null mice to investigate the consequence of total adipocyte deficienc...

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Principais autores: Maria-Bernadette Madel, He Fu, Dominique D. Pierroz, Mariano Schiffrin, Carine Winkler, Anne Wilson, Cécile Pochon, Barbara Toffoli, Mahdia Taïeb, Jean-Yves Jouzeau, Federica Gilardi, Serge Ferrari, Nicolas Bonnet, Claudine Blin-Wakkach, Béatrice Desvergne, David Moulin
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2021-04-01
Serier:Frontiers in Cell and Developmental Biology
Fag:
adiponectin
osteoclast
bone marrow adiposity
cortical bone porosity
AMPK
Online adgang:https://www.frontiersin.org/articles/10.3389/fcell.2021.627153/full
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