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Estrogen deficiency induces bone loss by enhancing T-cell production of TNF-α

Estrogen deficiency induces bone loss by upregulating osteoclastogenesis by mechanisms not completely defined. We found that ovariectomy-enhanced T-cell production of TNF-α, which, acting through the TNF-α receptor p55, augments macrophage colony-stimulating factor–induced (M-CSF–induced) and RANKL-...

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Bibliografiske detaljer
Main Authors: Cenci, Simone, Weitzmann, M. Neale, Roggia, Cristiana, Namba, Noriyuki, Novack, Deborah, Woodring, Jessica, Pacifici, Roberto
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2000
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC381439/
https://ncbi.nlm.nih.gov/pubmed/11086024
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