Structural and functional insights into the molecular mechanism of rRNA m6A methyltransferase RlmJ

RlmJ catalyzes the m(6)A2030 methylation of 23S rRNA during ribosome biogenesis in Escherichia coli. Here, we present crystal structures of RlmJ in apo form, in complex with the cofactor S-adenosyl-methionine and in complex with S-adenosyl-homocysteine plus the substrate analogue adenosine monophosp...

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Hlavní autoři: Punekar, Avinash S., Liljeruhm, Josefine, Shepherd, Tyson R., Forster, Anthony C., Selmer, Maria
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2013
Témata:
Structural Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3814359/
https://ncbi.nlm.nih.gov/pubmed/23945937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt719
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