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Structural and functional insights into the molecular mechanism of rRNA m6A methyltransferase RlmJ

RlmJ catalyzes the m(6)A2030 methylation of 23S rRNA during ribosome biogenesis in Escherichia coli. Here, we present crystal structures of RlmJ in apo form, in complex with the cofactor S-adenosyl-methionine and in complex with S-adenosyl-homocysteine plus the substrate analogue adenosine monophosp...

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Autors principals: Punekar, Avinash S., Liljeruhm, Josefine, Shepherd, Tyson R., Forster, Anthony C., Selmer, Maria
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3814359/
https://ncbi.nlm.nih.gov/pubmed/23945937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt719
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