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Efficient generation of large-scale genome-modified mice using gRNA and CAS9 endonuclease
The generation of genome-modified animals is a powerful approach to analyze gene functions. The CAS9/guide RNA (gRNA) system is expected to become widely used for the efficient generation of genome-modified animals, but detailed studies on optimum conditions and availability are limited. In the pres...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3814358/ https://ncbi.nlm.nih.gov/pubmed/23997119 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt772 |
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