PTEN has tumor promoting properties in the setting of gain-of-function p53 mutations

We show, for the first time, that the tumor suppressor PTEN can have tumor promoting properties. We demonstrate that PTEN acquires these unexpected properties by enhancing gain-of-function mutant p53 (mut-p53) protein levels. We find that PTEN restoration to cells harboring mut-p53 leads to inductio...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Li, Yunqing, Guessous, Fadila, Kwon, Sherwin, Kumar, Manish, Ibidapo, Opeyemi, Fuller, Lauren, Johnson, Elizabeth, Lal, Bachchu, Hussaini, Isa, Bao, Yongde, Laterra, John, Schiff, David, Abounader, Roger
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3813002/
https://ncbi.nlm.nih.gov/pubmed/18339852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-07-1963
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados