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Bioconjugation by Native Chemical Tagging of C–H Bonds
A general C–H functionalization method for the tagging of natural products and pharmaceuticals is described. An azide-containing sulfinate reagent allows the appendage of azidoalkyl chains onto heteroaromatics, the product of which can then be attached to a monoclonal antibody by a “click” reaction....
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| Main Authors: | , , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2013
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3812917/ https://ncbi.nlm.nih.gov/pubmed/23957305 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja407739y |
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