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Bioconjugation by Native Chemical Tagging of C–H Bonds

A general C–H functionalization method for the tagging of natural products and pharmaceuticals is described. An azide-containing sulfinate reagent allows the appendage of azidoalkyl chains onto heteroaromatics, the product of which can then be attached to a monoclonal antibody by a “click” reaction....

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Detalhes bibliográficos
Main Authors: Zhou, Qianghui, Gui, Jinghan, Pan, Chung-Mao, Albone, Earl, Cheng, Xin, Suh, Edward M., Grasso, Luigi, Ishihara, Yoshihiro, Baran, Phil S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3812917/
https://ncbi.nlm.nih.gov/pubmed/23957305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja407739y
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