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FGFR3 DIMER STABILIZATION DUE TO A SINGLE AMINO ACID PATHOGENIC MUTATION
Mutations in the transmembrane (TM) domains of receptor tyrosine kinases (RTKs) have been implicated in the induction of pathological phenotypes. These mutations are believed to stabilize the RTK dimers, and thus promote unregulated signaling. However, the energetics behind the pathology induction h...
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| Auteurs principaux: | , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2005
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3812913/ https://ncbi.nlm.nih.gov/pubmed/16384584 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2005.11.077 |
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