FGFR3 DIMER STABILIZATION DUE TO A SINGLE AMINO ACID PATHOGENIC MUTATION

Mutations in the transmembrane (TM) domains of receptor tyrosine kinases (RTKs) have been implicated in the induction of pathological phenotypes. These mutations are believed to stabilize the RTK dimers, and thus promote unregulated signaling. However, the energetics behind the pathology induction h...

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Bibliographic Details
Main Authors: Li, Edwin, You, Min, Hristova, Kalina
Format: Artigo
Language:Inglês
Published: 2005
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3812913/
https://ncbi.nlm.nih.gov/pubmed/16384584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2005.11.077
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