Coupled activation-degradation of eEF2K regulates protein synthesis in response to genotoxic stress

eEF2K is a kinase that controls the rate of peptide chain elongation by phosphorylating eukaryotic Elongation Factor 2 (eEF2), the protein that mediates the movement of the ribosome along the mRNA by promoting translocation from the A to the P site. eEF2K-mediated phosphorylation of eEF2 on Thr(56)...

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Main Authors: Kruiswijk, Flore, Yuniati, Laurensia, Magliozzi, Roberto, Low, Teck Yew, Lim, Ratna, Bolder, Renske, Mohammed, Shabaz, Proud, Christopher G., Heck, Albert J. R., Pagano, Michele, Guardavaccaro, Daniele
Format: Artigo
Jezik:Inglês
Izdano: 2012
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3812825/
https://ncbi.nlm.nih.gov/pubmed/22669845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2002718
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