STRUCTURAL VARIATION GOVERNS SUBSTRATE SPECIFICITY FOR ORGANIC ANION TRANSPORTERS (OAT) HOMOLOGS: POTENTIAL REMOTE SENSING BY OAT FAMILY MEMBERS

Organic Anion Transporters (OATs, SLC22) interact with a remarkably diverse array of endogenous and exogenous organic anions. However, little is known about the structural features that determine their substrate selectivity. We examined the substrate binding preferences and transport function of olf...

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Bibliographic Details
Main Authors: Kaler, Gregory, Truong, David M., Khandelwal, Akash, Nagle, Megha, Eraly, Satish A., Swaan, Peter W., Nigam, Sanjay K.
Format: Artigo
Language:Inglês
Published: 2007
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3812435/
https://ncbi.nlm.nih.gov/pubmed/17553798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M703467200
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