STRUCTURAL VARIATION GOVERNS SUBSTRATE SPECIFICITY FOR ORGANIC ANION TRANSPORTERS (OAT) HOMOLOGS: POTENTIAL REMOTE SENSING BY OAT FAMILY MEMBERS

Organic Anion Transporters (OATs, SLC22) interact with a remarkably diverse array of endogenous and exogenous organic anions. However, little is known about the structural features that determine their substrate selectivity. We examined the substrate binding preferences and transport function of olf...

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Autores principales: Kaler, Gregory, Truong, David M., Khandelwal, Akash, Nagle, Megha, Eraly, Satish A., Swaan, Peter W., Nigam, Sanjay K.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2007
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3812435/
https://ncbi.nlm.nih.gov/pubmed/17553798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M703467200
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