In Vivo Readout of CFTR Function: Ratiometric Measurement of CFTR-Dependent Secretion by Individual, Identifiable Human Sweat Glands

To assess CFTR function in vivo, we developed a bioassay that monitors and compares CFTR-dependent and CFTR-independent sweat secretion in parallel for multiple (∼50) individual, identified glands in each subject. Sweating was stimulated by intradermally injected agonists and quantified by optically...

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Detalhes bibliográficos
Main Authors: Wine, Jeffrey J., Char, Jessica E., Chen, Jonathan, Cho, Hyung-ju, Dunn, Colleen, Frisbee, Eric, Joo, Nam Soo, Milla, Carlos, Modlin, Sara E., Park, Il-Ho, Thomas, Ewart A. C., Tran, Kim V., Verma, Rohan, Wolfe, Marlene H.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3811985/
https://ncbi.nlm.nih.gov/pubmed/24204751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0077114
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