Deletion of Cdc42 Enhances ADAM17-Mediated Vascular Endothelial Growth Factor Receptor 2 Shedding and Impairs Vascular Endothelial Cell Survival and Vasculogenesis

Cdc42 is a Ras-related GTPase that plays an important role in the regulation of a range of cellular functions, including cell migration, proliferation, and survival. Consistent with its critical functions in vitro, the inactivation of Cdc42 in mice has been shown to result in embryonic lethality at...

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Hauptverfasser: Jin, Yixin, Liu, Yang, Lin, Qiong, Li, Jieli, Druso, Joseph E., Antonyak, Marc A., Meininger, Cynthia J., Zhang, Shenyuan L., Dostal, David E., Guan, Jun-Lin, Cerione, Richard A., Peng, Xu
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2013
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3811890/
https://ncbi.nlm.nih.gov/pubmed/23979594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00650-13
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