Genomic Characterization of Ciprofloxacin Resistance in a Laboratory-Derived Mutant and a Clinical Isolate of Streptococcus pneumoniae

The broad-spectrum fluoroquinolone ciprofloxacin is a bactericidal antibiotic targeting DNA topoisomerase IV and DNA gyrase encoded by the parC and gyrA genes. Resistance to ciprofloxacin in Streptococcus pneumoniae mainly occurs through the acquisition of mutations in the quinolone resistance-deter...

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Autores principales: Lupien, Andréanne, Billal, Dewan S., Fani, Fereshteh, Soualhine, Hafid, Zhanel, George G., Leprohon, Philippe, Ouellette, Marc
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2013
Materias:
Mechanisms of Resistance
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3811476/
https://ncbi.nlm.nih.gov/pubmed/23877698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00418-13
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