Safety, Tolerability, Pharmacokinetics, and Antiviral Activity of GSK2336805, an Inhibitor of Hepatitis C Virus (HCV) NS5A, in Healthy Subjects and Subjects Chronically Infected with HCV Genotype 1

GSK2336805 is an orally bioavailable hepatitis C virus (HCV) inhibitor working through an NS5A-mediated mechanism. This first-time-in-human study was conducted to assess the safety, tolerability, pharmacokinetics, metabolism, and efficacy of GSK2336805 in healthy subjects and subjects infected with...

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Bibliographische Detailangaben
Hauptverfasser: Wilfret, D. A., Walker, J., Adkison, K. K., Jones, L. A., Lou, Y., Gan, J., Castellino, S., Moseley, C. L., Horton, J., de Serres, M., Culp, A., Goljer, I., Spreen, W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2013
Schlagworte:
Antiviral Agents
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3811459/
https://ncbi.nlm.nih.gov/pubmed/23896477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00910-13
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