Impaired Virulence and Fitness of a Colistin-Resistant Clinical Isolate of Acinetobacter baumannii in a Rat Model of Pneumonia

We compared the fitness and lung pathogenicity of two isogenic clinical isolates of Acinetobacter baumannii, one resistant (ABCR) and the other susceptible (ABCS) to colistin. In vitro, ABCR exhibited slower growth kinetics than ABCS. In a rat model of pneumonia, ABCR was associated with less pronou...

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Main Authors: Hraiech, Sami, Roch, Antoine, Lepidi, Hubert, Atieh, Thérèse, Audoly, Gilles, Rolain, Jean-Marc, Raoult, Didier, Brunel, Jean-Michel, Papazian, Laurent, Brégeon, Fabienne
格式: Artigo
語言:Inglês
出版: American Society for Microbiology 2013
主題:
Mechanisms of Resistance
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3811450/
https://ncbi.nlm.nih.gov/pubmed/23836181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00700-13
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