Inhaled Lactonase Reduces Pseudomonas aeruginosa Quorum Sensing and Mortality in Rat Pneumonia

RATIONALE: The effectiveness of antibiotic molecules in treating Pseudomonas aeruginosa pneumonia is reduced as a result of the dissemination of bacterial resistance. The existence of bacterial communication systems, such as quorum sensing, has provided new opportunities of treatment. Lactonases eff...

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Detalhes bibliográficos
Main Authors: Hraiech, Sami, Hiblot, Julien, Lafleur, John, Lepidi, Hubert, Papazian, Laurent, Rolain, Jean-Marc, Raoult, Didier, Elias, Mikael, Silby, Mark W., Bzdrenga, Janek, Bregeon, Fabienne, Chabriere, Eric
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4211673/
https://ncbi.nlm.nih.gov/pubmed/25350373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0107125
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