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Impaired Virulence and Fitness of a Colistin-Resistant Clinical Isolate of Acinetobacter baumannii in a Rat Model of Pneumonia

We compared the fitness and lung pathogenicity of two isogenic clinical isolates of Acinetobacter baumannii, one resistant (ABCR) and the other susceptible (ABCS) to colistin. In vitro, ABCR exhibited slower growth kinetics than ABCS. In a rat model of pneumonia, ABCR was associated with less pronou...

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Hlavní autoři: Hraiech, Sami, Roch, Antoine, Lepidi, Hubert, Atieh, Thérèse, Audoly, Gilles, Rolain, Jean-Marc, Raoult, Didier, Brunel, Jean-Michel, Papazian, Laurent, Brégeon, Fabienne
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2013
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3811450/
https://ncbi.nlm.nih.gov/pubmed/23836181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00700-13
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