Impaired Virulence and Fitness of a Colistin-Resistant Clinical Isolate of Acinetobacter baumannii in a Rat Model of Pneumonia

We compared the fitness and lung pathogenicity of two isogenic clinical isolates of Acinetobacter baumannii, one resistant (ABCR) and the other susceptible (ABCS) to colistin. In vitro, ABCR exhibited slower growth kinetics than ABCS. In a rat model of pneumonia, ABCR was associated with less pronou...

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Bibliografski detalji
Glavni autori: Hraiech, Sami, Roch, Antoine, Lepidi, Hubert, Atieh, Thérèse, Audoly, Gilles, Rolain, Jean-Marc, Raoult, Didier, Brunel, Jean-Michel, Papazian, Laurent, Brégeon, Fabienne
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2013
Teme:
Mechanisms of Resistance
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3811450/
https://ncbi.nlm.nih.gov/pubmed/23836181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00700-13
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