Impaired Virulence and Fitness of a Colistin-Resistant Clinical Isolate of Acinetobacter baumannii in a Rat Model of Pneumonia

We compared the fitness and lung pathogenicity of two isogenic clinical isolates of Acinetobacter baumannii, one resistant (ABCR) and the other susceptible (ABCS) to colistin. In vitro, ABCR exhibited slower growth kinetics than ABCS. In a rat model of pneumonia, ABCR was associated with less pronou...

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Detalhes bibliográficos
Main Authors: Hraiech, Sami, Roch, Antoine, Lepidi, Hubert, Atieh, Thérèse, Audoly, Gilles, Rolain, Jean-Marc, Raoult, Didier, Brunel, Jean-Michel, Papazian, Laurent, Brégeon, Fabienne
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
Assuntos:
Mechanisms of Resistance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3811450/
https://ncbi.nlm.nih.gov/pubmed/23836181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00700-13
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