Association of Higher Plasma Vitamin D Binding Protein and Lower Free Calcitriol Levels with Tenofovir Disoproxil Fumarate Use and Plasma and Intracellular Tenofovir Pharmacokinetics: Cause of a Functional Vitamin D Deficiency?

Tenofovir disoproxil fumarate (TDF) causes bone, endocrine, and renal changes by an unknown mechanism(s). Data are limited on tenofovir pharmacokinetics and these effects. Using baseline data from a multicenter study of HIV-infected youth on stable treatment with regimens containing TDF (n = 118) or...

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Main Authors: Havens, Peter L., Kiser, Jennifer J., Stephensen, Charles B., Hazra, Rohan, Flynn, Patricia M., Wilson, Craig M., Rutledge, Brandy, Bethel, James, Pan, Cynthia G., Woodhouse, Leslie R., Van Loan, Marta D., Liu, Nancy, Lujan-Zilbermann, Jorge, Baker, Alyne, Kapogiannis, Bill G., Gordon, Catherine M., Mulligan, Kathleen
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2013
Fag:
Antiviral Agents
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3811269/
https://ncbi.nlm.nih.gov/pubmed/24002093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01096-13
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