Association of Higher Plasma Vitamin D Binding Protein and Lower Free Calcitriol Levels with Tenofovir Disoproxil Fumarate Use and Plasma and Intracellular Tenofovir Pharmacokinetics: Cause of a Functional Vitamin D Deficiency?

Tenofovir disoproxil fumarate (TDF) causes bone, endocrine, and renal changes by an unknown mechanism(s). Data are limited on tenofovir pharmacokinetics and these effects. Using baseline data from a multicenter study of HIV-infected youth on stable treatment with regimens containing TDF (n = 118) or...

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Detalhes bibliográficos
Main Authors: Havens, Peter L., Kiser, Jennifer J., Stephensen, Charles B., Hazra, Rohan, Flynn, Patricia M., Wilson, Craig M., Rutledge, Brandy, Bethel, James, Pan, Cynthia G., Woodhouse, Leslie R., Van Loan, Marta D., Liu, Nancy, Lujan-Zilbermann, Jorge, Baker, Alyne, Kapogiannis, Bill G., Gordon, Catherine M., Mulligan, Kathleen
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3811269/
https://ncbi.nlm.nih.gov/pubmed/24002093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01096-13
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