Flucytosine Antagonism of Azole Activity versus Candida glabrata: Role of Transcription Factor Pdr1 and Multidrug Transporter Cdr1

Infections with the opportunistic yeast Candida glabrata have increased dramatically in recent years. Antifungal therapy of yeast infections commonly employs azoles, such as fluconazole (FLC), but C. glabrata frequently develops resistance to these inhibitors of ergosterol biosynthesis. The pyrimidi...

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Bibliografiske detaljer
Main Authors: Steier, Zoë, Vermitsky, John-Paul, Toner, Geoffrey, Gygax, Scott E., Edlind, Thomas, Katiyar, Santosh
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2013
Fag:
Mechanisms of Resistance
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3811237/
https://ncbi.nlm.nih.gov/pubmed/23979762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02394-12
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