Flucytosine Antagonism of Azole Activity versus Candida glabrata: Role of Transcription Factor Pdr1 and Multidrug Transporter Cdr1

Infections with the opportunistic yeast Candida glabrata have increased dramatically in recent years. Antifungal therapy of yeast infections commonly employs azoles, such as fluconazole (FLC), but C. glabrata frequently develops resistance to these inhibitors of ergosterol biosynthesis. The pyrimidi...

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Main Authors: Steier, Zoë, Vermitsky, John-Paul, Toner, Geoffrey, Gygax, Scott E., Edlind, Thomas, Katiyar, Santosh
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2013
Assuntos:
Mechanisms of Resistance
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3811237/
https://ncbi.nlm.nih.gov/pubmed/23979762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02394-12
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