Infusion of donor-derived CD19-redirected virus-specific T cells for B-cell malignancies relapsed after allogeneic stem cell transplant: a phase 1 study

Autologous T cells expressing a CD19-specific chimeric antigen receptor (CD19.CAR) are active against B-cell malignancies, but it is unknown whether allogeneic CD19.CAR T cells are safe or effective. After allogeneic hematopoietic stem cell transplantation (HSCT), infused donor-derived virus-specifi...

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Main Authors: Cruz, Conrad Russell Y., Micklethwaite, Kenneth P., Savoldo, Barbara, Ramos, Carlos A., Lam, Sharon, Ku, Stephanie, Diouf, Oumar, Liu, Enli, Barrett, A. John, Ito, Sawa, Shpall, Elizabeth J., Krance, Robert A., Kamble, Rammurti T., Carrum, George, Hosing, Chitra M., Gee, Adrian P., Mei, Zhuyong, Grilley, Bambi J., Heslop, Helen E., Rooney, Cliona M., Brenner, Malcolm K., Bollard, Catherine M., Dotti, Gianpietro
Format: Artigo
Jezik:Inglês
Izdano: American Society of Hematology 2013
Teme:
Clinical Trials and Observations
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3811171/
https://ncbi.nlm.nih.gov/pubmed/24030379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-06-506741
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