Combination of vinblastine and oncolytic herpes simplex virus vector expressing IL-12 therapy increases antitumor and antiangiogenic effects in prostate cancer models

Oncolytic herpes simplex virus-1 (oHSV)–based vectors selectively replicate in tumor cells causing direct killing, ie., oncolysis, while sparing normal cells. oHSV’sare promising anticancer agents, but their efficacy, when used as single agents, leaves room for improvement. We hypothesized that comb...

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Autores principales: Passer, Brent J., Cheema, Tooba, Wu, Shulin, Wu, Chen-lee, Rabkin, Samuel D., Martuza, Robert L.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2012
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3810211/
https://ncbi.nlm.nih.gov/pubmed/23138870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cgt.2012.75
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