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Basal and Antigen-Induced Exposure of the Proline-Rich Sequence in CD3ε
The CD3ε cytoplasmic tail contains a conserved proline-rich sequence (PRS) that influences TCR–CD3 expression and signaling. Although the PRS can bind the SH3.1 domain of the cytosolic adapter Nck, whether the PRS is constitutively available for Nck binding or instead represents a cryptic motif that...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3810001/ https://ncbi.nlm.nih.gov/pubmed/21228347 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1003225 |
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