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Molecular basis for Proline- and Arginine-Rich Peptide inhibition of proteasome

PR39, a naturally occurring and cell-permeable proline-and arginine-rich peptide, blocks the degradation of IκBα hereby attenuating inflammation. It is a non-competitive and reversible inhibitor of 20S proteasome. To identify its basis of action, we used solution NMR spectroscopy and mutational anal...

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Bibliografski detalji
Glavni autori: Anbanandam, Asokan, Albarado, Diana C., Tirziu, Daniela C., Simons, Michael, Veeraraghavan, Sudha
Format: Artigo
Jezik:Inglês
Izdano: 2008
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2632303/
https://ncbi.nlm.nih.gov/pubmed/18823992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2008.09.021
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