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Molecular basis for Proline- and Arginine-Rich Peptide inhibition of proteasome
PR39, a naturally occurring and cell-permeable proline-and arginine-rich peptide, blocks the degradation of IκBα hereby attenuating inflammation. It is a non-competitive and reversible inhibitor of 20S proteasome. To identify its basis of action, we used solution NMR spectroscopy and mutational anal...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2632303/ https://ncbi.nlm.nih.gov/pubmed/18823992 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2008.09.021 |
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