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Insights into transcription enhancer factor 1 (TEF-1) activity from the solution structure of the TEA domain
Transcription enhancer factor 1 is essential for cardiac, skeletal, and smooth muscle development and uses its N-terminal TEA domain (TEAD) to bind M-CAT elements. Here, we present the first structure of TEAD and show that it is a three-helix bundle with a homeodomain fold. Structural data reveal ho...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1859914/ https://ncbi.nlm.nih.gov/pubmed/17085591 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0607171103 |
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