The Proline-Rich Sequence of CD3ε as an amplifier of low-avidity TCR signaling

Engagement of peptide-MHC (pMHC) by the T-cell receptor induces a conformational change in CD3ε that exposes a proline-rich sequence (PRS) and recruits the cytoskeletal adaptor Nck. This event, which precedes phosphorylation of the CD3ε ITAM, has been implicated in synapse formation and T-cell funct...

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Autores principales: Tailor, Pankaj, Tsai, Sue, Shameli, Afshin, Serra, Pau, Wang, Jinguo, Robbins, Stephen, Nagata, Masao, Szymczak-Workman, Andrea L., Vignali, Dario A. A., Santamaria, Pere
Formato: Artigo
Lenguaje:Inglês
Publicado: 2008
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2665931/
https://ncbi.nlm.nih.gov/pubmed/18566390
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