Developmental control of CD8(+) T cell–avidity maturation in autoimmune diabetes

The progression of immune responses is generally associated with an increase in the overall avidity of antigen-specific T cell populations for peptide-MHC. This is thought to result from preferential expansion of high-avidity clonotypes at the expense of their low-avidity counterparts. Since T cell...

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Autores principales: Han, Bingye, Serra, Pau, Yamanouchi, Jun, Amrani, Abdelaziz, Elliott, John F., Dickie, Peter, DiLorenzo, Teresa P., Santamaria, Pere
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2005
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1142112/
https://ncbi.nlm.nih.gov/pubmed/15937548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI24219
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