Systematic Discovery of TLR Signaling Components Delineates Viral-Sensing Circuits

Deciphering the signaling networks that underlie normal and disease processes remains a major challenge. Here, we report the discovery of signaling components involved in the Toll-like receptor (TLR) response of immune dendritic cells (DCs), including a previously unkown pathway shared across mammal...

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Main Authors: Chevrier, Nicolas, Mertins, Philipp, Artyomov, Maxim N., Shalek, Alex K., Iannacone, Matteo, Ciaccio, Mark F., Gat-Viks, Irit, Tonti, Elena, DeGrace, Marciela M., Clauser, Karl R., Garber, Manuel, Eisenhaure, Thomas M., Yosef, Nir, Robinson, Jacob, Sutton, Amy, Andersen, Mette S., Root, David E., von Andrian, Ulrich, Jones, Richard B., Park, Hongkun, Carr, Steven A., Regev, Aviv, Amit, Ido, Hacohen, Nir
Format: Artigo
Language:Inglês
Published: 2011
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3809888/
https://ncbi.nlm.nih.gov/pubmed/22078882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2011.10.022
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