Chronic itch development in sensory neurons requires BRAF signaling pathways

Chronic itch, or pruritus, is associated with a wide range of skin abnormalities. The mechanisms responsible for chronic itch induction and persistence remain unclear. We developed a mouse model in which a constitutively active form of the serine/threonine kinase BRAF was expressed in neurons gated...

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Autors principals: Zhao, Zhong-Qiu, Huo, Fu-Quan, Jeffry, Joseph, Hampton, Lori, Demehri, Shadmehr, Kim, Seungil, Liu, Xian-Yu, Barry, Devin M., Wan, Li, Liu, Zhong-Chun, Li, Hui, Turkoz, Ahu, Ma, Kaijie, Cornelius, Lynn A., Kopan, Raphael, Battey, James F., Zhong, Jian, Chen, Zhou-Feng
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2013
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3809799/
https://ncbi.nlm.nih.gov/pubmed/24216512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI70528
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