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Epidermal Notch1 loss promotes skin tumorigenesis by impacting the stromal microenvironment
Notch1 is a proto-oncogene in several organs. In the skin, however, Notch1 deletion leads to tumor formation, suggesting that Notch1 is a “tumor suppressor” within this context. Here we demonstrate that, unlike classical tumor suppressors, Notch1 loss in epidermal keratinocytes promotes tumorigenesi...
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| Glavni autori: | , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2009
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2705757/ https://ncbi.nlm.nih.gov/pubmed/19573812 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2009.05.016 |
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