A nonclassical vitamin D receptor pathway suppresses renal fibrosis

The TGF-β superfamily comprises pleiotropic cytokines that regulate SMAD and non-SMAD signaling. TGF-β–SMAD signal transduction is known to be involved in tissue fibrosis, including renal fibrosis. Here, we found that 1,25-dihydroxyvitamin D(3)–bound [1,25(OH)(2)D(3)-bound] vitamin D receptor (VDR)...

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Detalhes bibliográficos
Main Authors: Ito, Ichiaki, Waku, Tsuyoshi, Aoki, Masato, Abe, Rumi, Nagai, Yu, Watanabe, Tatsuya, Nakajima, Yuka, Ohkido, Ichiro, Yokoyama, Keitaro, Miyachi, Hiroyuki, Shimizu, Toshiyuki, Murayama, Akiko, Kishimoto, Hiroyuki, Nagasawa, Kazuo, Yanagisawa, Junn
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3809783/
https://ncbi.nlm.nih.gov/pubmed/24135137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI67804
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