Functions of eIF3 downstream of 48S assembly impact AUG recognition and GCN4 translational control

The binding of eIF2–GTP–tRNA(i)(Met) ternary complex (TC) to 40S subunits is impaired in yeast prt1-1 (eIF3b) mutant extracts, but evidence is lacking that TC recruitment is a critical function of eIF3 in vivo. If TC binding was rate-limiting in prt1-1 cells, overexpressing TC should suppress the te...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Nielsen, Klaus H, Szamecz, Béla, Valášek, Leoš, Jivotovskaya, Antonina, Shin, Byung-Sik, Hinnebusch, Alan G
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2004
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC380973/
https://ncbi.nlm.nih.gov/pubmed/14976554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600116
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