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A Critical Role for the Putative NCS2 Nucleobase Permease YjcD in the Sensitivity of Escherichia coli to Cytotoxic and Mutagenic Purine Analogs

The base analogs 6-N-hydroxylaminopurine (HAP) and 2-amino-HAP (AHAP) are potent mutagens in bacteria and eukaryotic organisms. Previously, we demonstrated that a defect in the Escherichia coli ycbX gene, encoding a molybdenum cofactor-dependent oxidoreductase, dramatically enhances sensitivity to t...

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Autors principals: Kozmin, Stanislav G., Stepchenkova, Elena I., Chow, Stephen C., Schaaper, Roel M.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Microbiology 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3809563/
https://ncbi.nlm.nih.gov/pubmed/24169576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.00661-13
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