Single Dose Pharmacokinetics of Oral Tenofovir in Plasma, Peripheral Blood Mononuclear Cells, Colonic Tissue, and Vaginal Tissue

HIV seroconversion outcomes in preexposure prophylaxis (PrEP) trials of oral tenofovir (TFV)-containing regimens are highly sensitive to drug concentration, yet less-than-daily dosing regimens are under study. Description of TFV and its active moiety, TFV diphosphate (TFV-DP), in blood, vaginal tiss...

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Dades bibliogràfiques
Autors principals: Louissaint, Nicolette A., Cao, Ying-Jun, Skipper, Paul L., Liberman, Rosa G., Tannenbaum, Steven R., Nimmagadda, Sridhar, Anderson, Jean R., Everts, Stephanie, Bakshi, Rahul, Fuchs, Edward J., Hendrix, Craig W.
Format: Artigo
Idioma:Inglês
Publicat: Mary Ann Liebert, Inc. 2013
Matèries:
Clinical Trials/Clinical Studies
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3809387/
https://ncbi.nlm.nih.gov/pubmed/23600365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/aid.2013.0044
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