Human α1-Antitrypsin Binds to Heat-Shock Protein gp96 and Protects from Endogenous gp96-Mediated Injury In vivo

The extracellular form of the abundant heat-shock protein, gp96, is involved in human autoimmune pathologies. In patients with type 1 diabetes, circulating gp96 is found to be elevated, and is bound to the acute-phase protein, α1-antitrypsin (AAT). The two molecules also engage intracellularly durin...

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Main Authors: Ochayon, David E., Mizrahi, Mark, Shahaf, Galit, Baranovski, Boris M., Lewis, Eli C.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Frontiers Media S.A. 2013
Ábhair:
Immunology
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3808895/
https://ncbi.nlm.nih.gov/pubmed/24191154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2013.00320
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