Par-4 Down-regulation Promotes Breast Cancer Recurrence by Preventing Multinucleation following Targeted Therapy

Most deaths from breast cancer result from tumor recurrence, but the mechanisms underlying tumor relapse are largely unknown. We now report that Par-4 is down-regulated during tumor recurrence and that Par-4 down-regulation is necessary and sufficient to promote recurrence. Tumor cells with low Par-...

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Main Authors: Alvarez, James V., Pan, Tien-chi, Ruth, Jason, Feng, Yi, Zhou, Alice, Pant, Dhruv, Grimley, Joshua S., Wandless, Thomas J., DeMichele, Angela, Chodosh, Lewis A.
Format: Artigo
Jezik:Inglês
Izdano: 2013
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3808871/
https://ncbi.nlm.nih.gov/pubmed/23770012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2013.05.007
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