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Mitoxantrone Analogues as Ligands for a Stem–Loop Structure of Tau Pre-mRNA
A series of mitoxantrone (MTX) analogues have been designed, synthesized, and evaluated for binding to and stabilizing a stem–loop structure that serves as a splicing regulatory element in the pre-mRNA of tau, which is involved in Alzheimer’s and other neurodegenerative diseases. Several compounds s...
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| Hlavní autoři: | , , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2009
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3808193/ https://ncbi.nlm.nih.gov/pubmed/19839622 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm9013407 |
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