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Mitoxantrone Analogues as Ligands for a Stem–Loop Structure of Tau Pre-mRNA

A series of mitoxantrone (MTX) analogues have been designed, synthesized, and evaluated for binding to and stabilizing a stem–loop structure that serves as a splicing regulatory element in the pre-mRNA of tau, which is involved in Alzheimer’s and other neurodegenerative diseases. Several compounds s...

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Bibliografiska uppgifter
Huvudupphovsmän: Liu, Yang, Peacey, Eleanor, Dickson, John, Donahue, Christine P., Zheng, Suxin, Varani, Gabriele, Wolfe, Michael S.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2009
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3808193/
https://ncbi.nlm.nih.gov/pubmed/19839622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm9013407
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