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Mitoxantrone Analogues as Ligands for a Stem–Loop Structure of Tau Pre-mRNA
A series of mitoxantrone (MTX) analogues have been designed, synthesized, and evaluated for binding to and stabilizing a stem–loop structure that serves as a splicing regulatory element in the pre-mRNA of tau, which is involved in Alzheimer’s and other neurodegenerative diseases. Several compounds s...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , , , , , , |
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| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2009
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3808193/ https://ncbi.nlm.nih.gov/pubmed/19839622 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm9013407 |
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