Structural basis for stabilization of the tau pre-mRNA splicing regulatory element by novatrone (mitoxantrone)

Some familial neurodegenerative diseases are associated with mutations that destabilize a putative stem-loop structure within an intronic region of the tau pre-mRNA and alter the production of tau protein isoforms by alternative splicing. Since stabilization of the stem loop reverses the splicing pa...

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Bibliographic Details
Main Authors: Zheng, Suxin, Chen, Yu, Donahue, Christine P., Wolfe, Michael S., Varani, Gabriele
Format: Artigo
Language:Inglês
Published: 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2759301/
https://ncbi.nlm.nih.gov/pubmed/19477420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2009.03.009
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