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Structural basis for stabilization of the tau pre-mRNA splicing regulatory element by novatrone (mitoxantrone)
Some familial neurodegenerative diseases are associated with mutations that destabilize a putative stem-loop structure within an intronic region of the tau pre-mRNA and alter the production of tau protein isoforms by alternative splicing. Since stabilization of the stem loop reverses the splicing pa...
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| Hlavní autoři: | , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2009
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2759301/ https://ncbi.nlm.nih.gov/pubmed/19477420 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2009.03.009 |
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