Loss of Corticostriatal and Thalamostriatal Synaptic Terminals Precedes Striatal Projection Neuron Pathology in Heterozygous Q140 Huntington’s Disease Mice

Motor slowing, forebrain white matter loss, and striatal shrinkage have been reported in premanifest Huntington’s disease (HD) prior to overt striatal neuron loss. We carried out detailed LM and EM studies in a genetically precise HD mimic, heterozygous Q140 HD knock-in mice, to examine the possibil...

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Hlavní autoři: Deng, Y.P., Wong, T., Bricker-Anthony, C., Deng, B., Reiner, A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3808190/
https://ncbi.nlm.nih.gov/pubmed/23969239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2013.08.009
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