In vivo assessment of the permeability of the blood-brain barrier and blood-retinal barrier to fluorescent indoline derivatives in zebrafish

BACKGROUND: Successful delivery of compounds to the brain and retina is a challenge in the development of therapeutic drugs and imaging agents. This challenge arises because internalization of compounds into the brain and retina is restricted by the blood–brain barrier (BBB) and blood-retinal barrie...

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Bibliografiske detaljer
Main Authors: Watanabe, Kohei, Nishimura, Yuhei, Nomoto, Tsuyoshi, Umemoto, Noriko, Zhang, Zi, Zhang, Beibei, Kuroyanagi, Junya, Shimada, Yasuhito, Shintou, Taichi, Okano, Mie, Miyazaki, Takeshi, Imamura, Takeshi, Tanaka, Toshio
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2012
Fag:
Methodology Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3807752/
https://ncbi.nlm.nih.gov/pubmed/22894547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2202-13-101
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