Isolate-Specific Differences in the Conformational Dynamics and Antigenicity of HIV-1 gp120

The HIV-1 envelope glycoprotein (Env) mediates viral entry into host cells and is the sole target of neutralizing antibodies. Much of the sequence diversity in the HIV-1 genome is concentrated within Env, particularly within its gp120 surface subunit. While dramatic functional diversity exists among...

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Bibliographic Details
Main Authors: Davenport, Thaddeus M., Guttman, Miklos, Guo, Wenjin, Cleveland, Brad, Kahn, Maria, Hu, Shiu-Lok, Lee, Kelly K.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2013
Subjects:
Structure and Assembly
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3807424/
https://ncbi.nlm.nih.gov/pubmed/23903848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01535-13
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