C-Reactive Protein (CRP) Is Essential for Efficient Systemic Transduction of Recombinant Adeno-Associated Virus Vector 1 (rAAV-1) and rAAV-6 in Mice

The clinical relevance of gene therapy using the recombinant adeno-associated virus (rAAV) vectors often requires widespread distribution of the vector, and in this case, systemic delivery is the optimal route of administration. Humoral blood factors, such as antibodies or complement, are the first...

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Detalhes bibliográficos
Main Authors: Denard, Jerome, Marolleau, Beatrice, Jenny, Christine, Rao, Tata Nageswara, Fehling, Hans Jörg, Voit, Thomas, Svinartchouk, Fedor
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
Assuntos:
Gene Delivery
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3807418/
https://ncbi.nlm.nih.gov/pubmed/23903832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01813-13
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