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Mammalian Adaptation in the PB2 Gene of Avian H5N1 Influenza Virus

The substitution of glutamic acid (E) for lysine (K) at position 627 of the PB2 protein of avian H5N1 viruses has been identified as a virulence and host range determinant for infection of mammals. Here, we report that the E-to-K host-adaptive mutation in the PB2 gene appeared from day 4 and 5 along...

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Detalhes bibliográficos
Main Authors: Min, Ji-Young, Santos, Celia, Fitch, Adam, Twaddle, Alan, Toyoda, Yoshiko, DePasse, Jay V., Ghedin, Elodie, Subbarao, Kanta
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3807384/
https://ncbi.nlm.nih.gov/pubmed/23864613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01016-13
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