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Mammalian Adaptation in the PB2 Gene of Avian H5N1 Influenza Virus
The substitution of glutamic acid (E) for lysine (K) at position 627 of the PB2 protein of avian H5N1 viruses has been identified as a virulence and host range determinant for infection of mammals. Here, we report that the E-to-K host-adaptive mutation in the PB2 gene appeared from day 4 and 5 along...
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| Autors principals: | , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Microbiology
2013
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3807384/ https://ncbi.nlm.nih.gov/pubmed/23864613 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01016-13 |
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