Mice Lacking Functional STAT1 Are Highly Susceptible to Lethal Infection with Lassa Virus

Lassa fever (LF) is a potentially lethal human disease that is caused by the arenavirus Lassa virus (LASV). Annually, around 300,000 infections with up to 10,000 deaths occur in regions of Lassa fever endemicity in West Africa. Here we demonstrate that mice lacking a functional STAT1 pathway are hig...

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Detalhes bibliográficos
Main Authors: Yun, Nadezhda E., Seregin, Alexey V., Walker, David H., Popov, Vsevolod L., Walker, Aida G., Smith, Jeanon N., Miller, Milagros, de la Torre, Juan C., Smith, Jennifer K., Borisevich, Viktoriya, Fair, Joseph N., Wauquier, Nadia, Grant, Donald S., Bockarie, Bayon, Bente, Dennis, Paessler, Slobodan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3807383/
https://ncbi.nlm.nih.gov/pubmed/23903830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01433-13
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