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Gag-Dependent Enrichment of HIV-1 RNA near the Uropod Membrane of Polarized T Cells

The enrichment of HIV-1 macromolecules at the uropod of polarized T cells can significantly promote virus assembly and cell-mediated infection. Using live-cell fluorescence microscopy, we demonstrate that full-length HIV-1 RNA is enriched at the uropod membrane; furthermore, the presence of HIV-1 Ga...

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Detalhes bibliográficos
Main Authors: Hatch, Steven C., Sardo, Luca, Chen, Jianbo, Burdick, Ryan, Gorelick, Robert, Fivash, Matthew J., Pathak, Vinay K., Hu, Wei-Shau
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3807364/
https://ncbi.nlm.nih.gov/pubmed/23966405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01680-13
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